Due to the unique side-effect profile of immune checkpoint inhibitors (ICIs), groups of patients deemed to be at high risk of complications were excluded from trials that proved the efficacy and safety of these agents in patients with various malignancies.Among these excluded patients were those with prior solid organ transplantation, chronic viral
Astrocytes are multifunctional glial cells that are essential for brain functioning.Most existing methods to induce astrocytes from stem cells are inefficient, requiring couples of weeks.Here, we designed an alginate hydrogel-based method to realize high-efficiency astrocytic differentiation from human neural stem cells.Comparing to the conventiona
Reverse charge mechanism is considered to be a specific mechanism when applying the value added tax.The liability to declare and pay the output tax is transferred to the recipient of the fulfillment within the reverse charge mechanism.Since Apri1 1, 2011 there has been extended the application of the reverse charge mechanism to the domestic (home)
Abstract Background The extent of the consequences of an episode of severe acute kidney injury (AKI) on long-term outcome of critically ill patients remain debated.We conducted a prospective follow-up of patients included in a large multicenter clinical trial of renal replacement therapy (RRT) initiation strategy during severe AKI (the Artificial K
ABSTRACTAll strains of the marine bacterium Vibrio parahaemolyticus harbor a type VI secretion system (T6SS) named T6SS2, suggesting that this system Lawn Decor plays an important role in the life cycle of this emerging pathogen.Although T6SS2 was recently shown to play a role in interbacterial competition, its effector repertoire remains unknown.H